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Nature Nanotech
 2013
DOI: 10.1038/nnano.2013.189
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Programmable chemical controllers made from DNA

Yuan-Jyue Chen
1
,
Neil Dalchau
2
,
Niranjan Srinivas
3
et al.

Abstract: Biological organisms use complex molecular networks to navigate their environment and regulate their internal state. The development of synthetic systems with similar capabilities could lead to applications such as smart therapeutics or fabrication methods based on self-organization. To achieve this, molecular control circuits need to be engineered to perform integrated sensing, computation and actuation. Here we report a DNA-based technology for implementing the computational core of such controllers. We use … Show more

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Cited by 510 publications

(506 citation statements)
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“… 2010 ), as recently demonstrated experimentally in Chen et al. ( 2013 ), the proposed designs are in principle implementable, and we have confirmed this in theory by modelling them in the two-domain setting (Cardelli 2010 ) using Visual DSD (Phillips and Cardelli 2009 ; Lakin et al. 2011 ).…”
Section: Discussionsupporting
confidence: 83%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“… 2010 ), as recently demonstrated experimentally in Chen et al. ( 2013 ), the proposed designs are in principle implementable, and we have confirmed this in theory by modelling them in the two-domain setting (Cardelli 2010 ) using Visual DSD (Phillips and Cardelli 2009 ; Lakin et al. 2011 ).…”
Section: Discussionsupporting
confidence: 83%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…3a,b,e). When using the experimentally calibrated rates from [17], we also found a similar pattern in the absence of leaks (Fig. 3c,e).…”
Section: Wave Propagation In An Autocatalytic Circuitsupporting
confidence: 68%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…However, the protocol takes longer to stabilize, up to O(n) time, since it does not stabilize until UniqueID stabilizes. 15 The next theorem shows a fast expected convergence time, and it completes the second portion of the main result, Theorem 3.1. First we establish some other claims necessary to prove Theorem 3.15.…”
Section: Exactcounting Converges In Fast Expected Timesupporting
confidence: 63%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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